Editorial: The Cytotoxicity and Apoptotic Effect of Nisin as an Effective Bacteriocin on the Cancer Cells

Document Type: Editorial


1 Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

2 Department of Urology, UroScience, State University of Campinas, Unicamp and Pontifical Catholic University of Campinas, PUC-Campinas, Campinas, SP, Brazil



Cancer is the second utmost dominant reason of death worldwide and the mortality rate is meaningfully increasing in the last decades. Different therapeutic approaches, comprising surgery, radiotherapy, chemotherapy are used for cancer treatment. Chemotherapy is only reasonably effective along with the adverse effects because of the non-selective cytotoxicity against target cells, relapse capacities, and appearance of multidrug-resistant (MDR) cells. Therefore, the search for novel anti-cancer agents with minimal toxicity for normal cells is significantly growing. A conceivable group under examination contains bacteriocins or antimicrobial peptides (AMPs) that have cytotoxic activity against several type of tumor cells. In this regard, Nisin is one of the natural AMPs produced by Lactococcus lactis. Some documents are presented regarding the cytotoxic properties of Nisin on numerous cancer cells. Considering that Nisin could make apoptosis through inherent pathways and cause cancer cell death, it was suggested that at appropriate doses it might be efficient and safe for cancer treatment, room for future studies.